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产品目录

PKR/EIF2AK2抗体图片
产品货号:
Z24078
中文名称:
PKR/EIF2AK2抗体
英文名称:
Anti-PKR/EIF2AK2 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PKR/EIF2AK2 Antibody
指标别名eIF 2A protein kinase 2;EIF2AK1;EIF2AK2;P1/eIF 2A protein kinase;p68 kinase;PKR;PRKR;Protein kinase RNA activated
克隆性Polyclonal
检验物种human
应用范围WB
基因名称EIF2AK2
抗体来源Rabbit
抗体类型IgG
免疫原A synthetic peptide corresponding to a sequence at the N-terminus of human PKR(2-18aa AGDLSAGFFMEELNTYR).
实际分子量62KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料EIF2AK2(Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2),also called PKR,is an enzyme that in humans is encoded by the EIF2AK2 gene.Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate,the alpha subunit of eukaryotic protein synthesis initiation factor-2,leading to the inhibition of protein synthesis(summary by Kuhen et al.,1996).By FISH analysis,Squire et al.(1993) assigned the EIF2AK2 gene to the boundary between chromosome 2p22-p21.Ben-Asouli et al.(2002) showed that human gamma-interferon mRNA uses local activation of PKR in the cell to control its own translation yield.IFNG mRNA was found to activate PKR through a pseudoknot in its 5-prime untranslated region.Taylor et al.(1999) studied the mechanism underlying the resistance of hepatitis C virus(HCV) to interferon.They demonstrated that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor EIF2-alpha,a target of PKR.E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth.
Uniprot IDP19525
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称eukaryotic translation initiation factor 2-alpha kinase 2
蛋白名全称Interferon-induced,double-stranded RNA-activated protein kinase
推荐稀释比
Western blot(WB) 1:500~2000

相关搜索:PKR/EIF2AK2抗体PKR抗体EIF2AK2多抗Anti-PKR/EIF2AK2 Antibody
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